Different types of molecular hydrogen donors and their pharmacokinetics in vivo.
- Author:
Bo-Yan LIU
1
;
Shu-Cun QIN
2
Author Information
1. Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China.
2. Key Laboratory of Atherosclerosis in Universities of Shandong Province, Institute of Atherosclerosis, Taishan Medical University, Taishan Institute for Hydrogen Biomedical Research, Taian 271000, China. scqin@tsmc.edu.cn.
- Publication Type:Journal Article
- MeSH:
Hydrogen;
administration & dosage;
pharmacokinetics
- From:
Acta Physiologica Sinica
2019;71(2):371-377
- CountryChina
- Language:Chinese
-
Abstract:
Molecular hydrogen (H) has been shown to have diverse biomedical effects. As a small molecular gas, hydrogen can be diffused to the target without hindrance. A variety of related hydrogen products used in medical research and public health have been developed. There are various methods of administration of H, mainly including inhaling hydrogen gas, drinking hydrogen water, injecting hydrogen-saline, orally taking solid-state H sustained-release agents, and stimulating intestinal microbiomes to produce hydrogen. Pharmacokinetics of H in vivo vary with methods of administration and thus influence its biomedical effects. This review summarizes the types of H donors and their pharmacokinetics in vivo.
