Research advances in endogenous neural stem cells promoting neural repair after ischemic stroke.
- Author:
Chang-Yun FANG
1
;
Xu-Sheng WU
1
;
Hang ZHANG
1
;
Yan-Ling GU
1
;
Shi-Bing WANG
1
;
Hui-Wen REN
1
;
Ke CHEN
1
;
Hui ZHANG
2
;
Bao-Hua CHENG
3
;
Yang GAO
4
Author Information
1. School of Clinical Medicine, Jining Medical University, Jining 272067, China.
2. College of Basic Medical Sciences, Jining Medical University, Jining 272067, China. zhhui0529@163.com.
3. College of Basic Medical Sciences, Jining Medical University, Jining 272067, China. chengbh1979@163.com.
4. College of Basic Medical Sciences, Jining Medical University, Jining 272067, China. gyjnmc2017@yeah.net.
- Publication Type:Journal Article
- MeSH:
Brain Ischemia;
therapy;
Humans;
Nerve Regeneration;
Neural Stem Cells;
cytology;
Stroke;
therapy
- From:
Acta Physiologica Sinica
2019;71(3):454-462
- CountryChina
- Language:Chinese
-
Abstract:
Neural stem cell therapy, as a new therapeutic method for neural diseases, has aroused a wide concern for over 20 years since neural stem cells were first found in 1992. Ischemic stroke is highly concerned because of its high incidence, mortality and disability rates. Because the brain has a limited ability to repair itself, to improve neural function and promote neural regeneration may help to prevent occurrence and development of neurological diseases. It is noteworthy that some stroke patients showed an ability to repair brain several months after the stroke happened, suggesting an existence of endogenous nerve repair in these patients. The research advances in functions of endogenous neural stem cells in neural regeneration and the related regulators after ischemic stroke are summarized in this review to provide new views of the mechanism of neural functional recovery after ischemic stroke.
