Mechanisms of adiponectin protection against diabetes-induced vascular endothelial injury.
- Author:
Yun-Hui DU
1
;
Xin-Liang MA
2
Author Information
1. Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
2. Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. xinma2006@gmail.com.
- Publication Type:Journal Article
- MeSH:
Adiponectin;
physiology;
Cardiovascular Diseases;
complications;
Diabetes Mellitus;
pathology;
Endothelium, Vascular;
physiopathology;
Humans
- From:
Acta Physiologica Sinica
2019;71(3):485-490
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality rates of diabetes with cardiovascular complications are continually rising, and diabetic cardiovascular disease is becoming a major public health issue that threatens human health. Acute endothelial dysfunction and chronic cellular damage caused by diabetes are important risk factors for diabetic cardiovascular disease and related mortality. Adiponectin is an adipocyte-derived molecule with significant cytoprotective effects, including the protection against diabetes-induced vascular endothelial injury. Here we review the mechanisms of adiponectin protective effects on acute vascular endothelial dysfunction and chronic structural damage induced by diabetes.
