Role of prostaglandin E receptor EP4 in the regulation of adipogenesis and adipose metabolism.
- Author:
Jing-Wei YU
1
;
Jun PENG
1
;
Xiao-Yan ZHANG
2
;
Wen SU
3
;
You-Fei GUAN
4
Author Information
1. Health Science Center, Shenzhen University, Shenzhen 518060, China.
2. Advanced Institute of Medical Science, Dalian Medical University, Dalian 116044, China.
3. Health Science Center, Shenzhen University, Shenzhen 518060, China. suwen@szu.edu.cn.
4. Advanced Institute of Medical Science, Dalian Medical University, Dalian 116044, China. guanyf@dmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Adipocytes;
Adipogenesis;
Adipose Tissue;
metabolism;
Humans;
Receptors, Prostaglandin E, EP4 Subtype;
physiology
- From:
Acta Physiologica Sinica
2019;71(3):491-496
- CountryChina
- Language:Chinese
-
Abstract:
Adipose tissue is the energy storage organ of the body, and excess energy is stored in adipocytes in the form of lipid droplets. The homeostasis of adipose tissue is the basis for the body to maintain normal metabolic activity. Prostaglandin E (PGE) is an important lipid mediator in the body. It is synthesized in almost all tissues and participates in the regulation of many physiological processes such as blood pressure, glucose and lipid metabolism, and inflammation. PGE is abundant in white adipose tissue, where it is involved in the regulation of fat metabolism. PGE plays its biological role through binding to four G protein coupled receptors (prostaglandin E receptors), including EP-1, -2, -3, and -4. The EP4 subtype has been proved to play an important role in adipogenesis and adipose metabolism: it could inhibit adipogenesis while it was activated, whereas its knockout could promote lipolysis. This review summarized the relationship between EP4 and adipose metabolism, hoping to identify new targets of drug development for metabolic disorders.
