Roles and mechanism of microRNAs in the regulation of skeletal muscle insulin resistance.
- Author:
Li-Fang ZHENG
1
;
Pei-Jie CHEN
1
;
Wei-Hua XIAO
2
Author Information
1. School of Kinesiology, Shanghai University of Sports, Shanghai 200438, China.
2. School of Kinesiology, Shanghai University of Sports, Shanghai 200438, China. xiaoweihua@sus.edu.cn.
- Publication Type:Journal Article
- MeSH:
Diabetes Mellitus, Type 2;
Humans;
Insulin;
Insulin Resistance;
MicroRNAs;
genetics;
Muscle, Skeletal;
physiology
- From:
Acta Physiologica Sinica
2019;71(3):497-504
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance is a common pathophysiological mechanism of obesity and type 2 diabetes mellitus. Skeletal muscle is one of the major target organs of insulin-mediated glucose uptake, metabolism and utilization, and it is the earliest and most important site of insulin resistance. Studies have shown that the impairments of glucose uptake, insulin signaling pathway and mitochondrial biosynthesis are closely related to skeletal muscle insulin resistance. When insulin resistance develops in skeletal muscle, multiple microRNAs (miRNAs) are up-regulated (miR-106b, miR-23a, miR-761, miR-135a, Let-7 and miR-29a) or down-regulated (miR-133a, miR-149 and miR-1). They participate in the regulation of skeletal muscle glucose uptake, insulin signaling pathway and mitochondrial biogenesis, and thus play important roles in the occurrence and development of skeletal muscle insulin resistance. Therefore, these miRNAs may serve as potential targets for the treatment of skeletal muscle insulin resistance or diabetes.
