Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats.
- Author:
Song WEN
1
;
Thiquynhnga NGUYEN
1
;
Wen-Ze XIAO
1
;
Chao-Xun WANG
1
;
Min GONG
1
;
Jian-Lan JIN
1
;
Li-Gang ZHOU
2
Author Information
1. Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.
2. Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China. zhouligang@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Eating;
drug effects;
Exenatide;
pharmacology;
Glucagon-Like Peptide-1 Receptor;
agonists;
Liraglutide;
pharmacology;
Random Allocation;
Rats;
Rats, Sprague-Dawley
- From:
Acta Physiologica Sinica
2019;71(4):514-526
- CountryChina
- Language:English
-
Abstract:
Glucagon-like peptide-1 (GLP-1) expression is shared by both intestinal cells and neurons of brainstem, which plays anorexigenic role on food intake. However, the exact source of physiological GLP-1 influencing food intake and pertinent mechanism of GLP-1 receptor agonists (GLP-1RA) remain unelucidated. In this study, the immediate early gene product c-Fos was chosen as the specific antigen for immunohistochemistry to show the certain areas of central nervous system (CNS) activation by the GLP-1RA. Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively. After injection, the amount of food intake and acute glycemic variation were assessed for comparison. The results showed that acute pharmacological dosage of GLP-1RA (Liraglutide or Exenatide) could significantly influence food intake. However, glycemic change indicated that the anorexic effect was dissociated with change in blood glucose in normal rats. Moreover, c-Fos was expressed significantly higher in major critical nuclei related to food intake in GLP-1RA groups when compared with the control group, and its expression was also found in spinal cord. The results suggested that acute administration of pharmacological doses of GLP-1 influences CNS via circulation and vagal pathways, especially on the arcuate nucleus (ARC) and the nucleus of solitary tract (NTS), and GLP-1 modulates autonomic nervous activities.
