Macrophages polarization and their role in chronic obstructive pulmonary disease.
- Author:
Yin LI
1
;
Jing LU
1
;
Yi ZHANG
1
;
Chen CHENG
1
;
Zi-Bing LIU
2
Author Information
1. Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China.
2. Acupuncture and Tuina College, Anhui University of Chinese Medicine, Hefei 230012, China. zibingliu@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Lung;
Macrophages;
cytology;
Pulmonary Disease, Chronic Obstructive;
pathology
- From:
Acta Physiologica Sinica
2019;71(4):604-612
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are highly plastic and can be polarized into classical activated macrophages (M1) and alternative activated macrophages (M2) under the induction of inflammatory factors and regulation of a variety of information molecules. Chronic pulmonary inflammation and pulmonary parenchyma injury are the main pathological manifestations of chronic obstructive pulmonary disease (COPD). M1 promotes pulmonary inflammation, whereas M2 inhibits inflammatory response, participates in lung tissue injury and repair, and swallows and removes pathogenic microorganisms and apoptotic cells. Target intervention in the polarization direction of macrophages may be a new strategy for COPD treatment.
