Research advance in circular RNAs.
- Author:
Yu-Han QI
1
;
Ze-Peng LIU
1
;
Wei-Jie ZHANG
1
;
Ping-Fan SHI
2
;
Shuang QIN
2
;
Zhi-Hua SHAO
3
Author Information
1. School of Stomatology, Tongji University, Shanghai 200092, China.
2. Department of Regenerative Medicine, School of Medicine, Tongji University, Shanghai 200092, China.
3. Department of Regenerative Medicine, School of Medicine, Tongji University, Shanghai 200092, China. zhihua_shao@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
RNA;
genetics;
Research;
trends
- From:
Acta Physiologica Sinica
2019;71(4):613-624
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNAs (circRNAs) are a class of endogenous, covalently closed, single-stranded RNA without 3'-poly(A) and 5'-cap structures. CircRNAs are characterized by universality, diversity, stability and conservation, and have been found to regulate mammalian transcription and be translated into proteins. In this review, we summarized the biogenesis, classification, expression, distribution, biological functions and regulation of circRNAs. In addition, we discussed the association of circRNAs with diseases and the methods for identification and characterization of circRNAs. Finally, we speculated the application prospect and research direction of circRNAs.
