Research progress on neural mechanism of peripheral inflammation in Parkinson's disease.
- Author:
Yong-Ting LIU
1
;
Ming-Hao SUN
1
;
Chun-Wei CAI
1
;
Chao REN
2
;
Hai-Chen NIU
3
Author Information
1. Department of Clinical Medicine, Xuzhou Medical University, Xuzhou 221004, China.
2. Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China. renchaotg@126.com.
3. Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China. nhcnhc@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood-Brain Barrier;
Dopaminergic Neurons;
pathology;
Humans;
Inflammation;
pathology;
Microglia;
Parkinson Disease;
pathology;
Substantia Nigra;
pathology;
alpha-Synuclein
- From:
Acta Physiologica Sinica
2019;71(5):732-740
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found that microglial cell activation and increased levels of pro-inflammatory factors were common features of PD brain tissue. At the same time, the invasion and accumulation of peripheric immune cells were detected in the brain of PD patients. In this paper, peripheral inflammation across the blood-brain barrier (BBB), the misfolded α-synuclein (α-syn)-induced microglial cell activation and intracerebral inflammation in PD are summarized, providing potential therapeutic measures for delaying the onset of PD.
