The Role of Synapsins in Neurological Disorders.
10.1007/s12264-017-0201-7
- Author:
Fatima Javed MIRZA
1
;
Saadia ZAHID
2
Author Information
1. Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
2. Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan. saadiazahid@hotmail.com.
- Publication Type:Journal Article
- Keywords:
Neurological disorders;
Synapsin I;
Synapsin II;
Synapsin III
- MeSH:
Animals;
Central Nervous System Diseases;
physiopathology;
Humans;
Synapsins;
physiology
- From:
Neuroscience Bulletin
2018;34(2):349-358
- CountryChina
- Language:English
-
Abstract:
Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication. Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins in maintaining brain physiology. In the recent times, increasing evidence has established the relevance of alterations in synapsins as a major determinant in many neurological disorders. Here, we give a comprehensive description of the diverse roles of the synapsin family and the underlying molecular mechanisms that contribute to several neurological disorders. These physiologically important roles of synapsins associated with neurological disorders are just beginning to be understood. A detailed understanding of the diversified expression of synapsins may serve to strategize novel therapeutic approaches for these debilitating neurological disorders.
