Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats.
10.1007/s12264-018-0208-8
- Author:
Renli QI
1
;
Jinghui LI
1
;
Xujun WU
2
;
Xin GENG
1
;
Nanhui CHEN
3
;
Hualin YU
4
Author Information
1. Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
2. The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
3. State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. nhchen@mail.kiz.ac.cn.
4. Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. yhl308@163.com.
- Publication Type:Journal Article
- Keywords:
Gamma band oscillation;
Ketamine;
Parvalbumin-positive basket cell;
Schizophrenia;
Sensory gating
- MeSH:
Acoustic Stimulation;
Analysis of Variance;
Animals;
Dose-Response Relationship, Drug;
Electroencephalography;
Excitatory Amino Acid Antagonists;
pharmacology;
Gamma Rhythm;
drug effects;
Ketamine;
pharmacology;
Male;
Prefrontal Cortex;
drug effects;
Rats;
Rats, Sprague-Dawley;
Sensory Gating;
drug effects;
Sleep Stages;
drug effects;
Statistics as Topic;
Time Factors;
Wakefulness;
drug effects
- From:
Neuroscience Bulletin
2018;34(3):457-464
- CountryChina
- Language:English
-
Abstract:
Gamma band oscillation (GBO) and sensory gating (SG) are associated with many cognitive functions. Ketamine induces deficits of GBO and SG in the prefrontal cortex (PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that (1) ketamine administration increased GBO power in the PFC in rats differently in the low- and high-dose groups; (2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and (3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power.
