AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
10.1007/s12264-018-0218-6
- Author:
Chunxia JIANG
1
;
Wanqing YANG
1
;
Zhihong FAN
1
;
Peng TENG
2
;
Ruyi MEI
2
;
Junlin YANG
1
;
Aifen YANG
1
;
Mengsheng QIU
3
;
Xiaofeng ZHAO
4
Author Information
1. Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China.
2. College of Life Sciences, Zhejiang University, Hangzhou, 310036, China.
3. Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China. m0qiu001@yahoo.com.
4. Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China. xiaofengzhao@yahoo.com.
- Publication Type:Journal Article
- Keywords:
AATYK;
Differentiation;
Oligodendrocytes
- MeSH:
Animals;
Animals, Newborn;
Apoptosis Regulatory Proteins;
genetics;
metabolism;
Cell Differentiation;
drug effects;
physiology;
Cell Proliferation;
drug effects;
genetics;
Cells, Cultured;
Cuprizone;
toxicity;
Demyelinating Diseases;
chemically induced;
metabolism;
pathology;
Embryo, Mammalian;
Gene Expression Regulation, Developmental;
genetics;
Ki-67 Antigen;
metabolism;
Mice;
Mice, Inbred C57BL;
Myelin Basic Protein;
metabolism;
Myelin Proteolipid Protein;
metabolism;
Myelin Sheath;
drug effects;
metabolism;
Oligodendroglia;
drug effects;
metabolism;
Protein-Tyrosine Kinases;
genetics;
metabolism;
RNA, Small Interfering;
genetics;
metabolism;
Rats;
Rats, Sprague-Dawley
- From:
Neuroscience Bulletin
2018;34(3):527-533
- CountryChina
- Language:English
-
Abstract:
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.
