Current Status of Neuromodulatory Therapies for Disorders of Consciousness.
10.1007/s12264-018-0244-4
- Author:
Xiaoyu XIA
1
;
Yi YANG
1
;
Yongkun GUO
2
;
Yang BAI
3
;
Yuanyuan DANG
1
;
Ruxiang XU
1
;
Jianghong HE
4
Author Information
1. Department of Neurosurgery, PLA Army General Hospital, Beijing, 100700, China.
2. Department of Neurosurgery, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450007, China.
3. International Vegetative State and Consciousness Science Institute, Hangzhou Normal University, Hangzhou, 311121, China.
4. Department of Neurosurgery, PLA Army General Hospital, Beijing, 100700, China. he_jianghong@sina.cn.
- Publication Type:Journal Article
- Keywords:
Deep brain stimulation;
Disorder of consciousness;
Neuromodulation;
Repetitive transcranial magnetic stimulation;
Spinal cord stimulation;
Transcranial direct current stimulation
- MeSH:
Brain;
drug effects;
physiopathology;
surgery;
Consciousness;
physiology;
Consciousness Disorders;
therapy;
Humans;
Neurotransmitter Agents;
therapeutic use;
Transcranial Magnetic Stimulation;
methods;
Treatment Outcome
- From:
Neuroscience Bulletin
2018;34(4):615-625
- CountryChina
- Language:English
-
Abstract:
Treatment for disorders of consciousness (DOCs) is still a Gordian knot. Evidence-based guidelines on the treatment of DOC patients are not currently available, while neuromodulation techniques are seen as a potential treatment. Multiple neuromodulation therapies have been applied. This article reviews the most relevant studies in the literature in order to describe a clear picture of the current state of neuromodulation therapies that could be used to treat DOC patients. Both invasive and non-invasive brain stimulation is discussed. Significant behavioral improvements in prolonged DOCs under neuromodulation therapies are rare. The efficacy of various such therapies remains a matter of debate. Further clinical investigations of existing techniques in larger samples properly controlling for spontaneous recovery are needed, and new approaches are awaited.
