Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury.
10.1007/s12264-018-0241-7
- Author:
Wendong YOU
1
;
Qilin TANG
1
;
Xiang WU
1
;
Junfeng FENG
1
;
Qing MAO
1
;
Guoyi GAO
2
;
Jiyao JIANG
1
Author Information
1. Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
2. Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. gao3@sina.com.
- Publication Type:Journal Article
- Keywords:
Acute brain injury;
Amplitude-integrated electroencephalography;
Coma;
Outcome
- MeSH:
Brain;
physiopathology;
Brain Injuries;
complications;
diagnosis;
physiopathology;
Coma;
diagnosis;
etiology;
physiopathology;
Electroencephalography;
methods;
Female;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Neurophysiological Monitoring;
methods;
Prognosis;
Prospective Studies;
Sensitivity and Specificity;
Severity of Illness Index
- From:
Neuroscience Bulletin
2018;34(4):639-646
- CountryChina
- Language:English
-
Abstract:
Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with aEEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. aEEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, aEEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury.
