Prenatal diagnosis by FISH technique in fetal cystic hygromas
- Author:
Tho Thi Quynh Nguyen
;
Huong Thi Thanh Tran
;
Hoan Thi Phan
;
Lan Thi Ngoc Hoang
;
Lan Thu Hoang
;
Cuong Danh Tran
;
Giang Truong Nguyen
- Publication Type:Journal Article
- Keywords:
cystic hygroma;
FISH technique;
chromosome
- MeSH:
cystic hygroma;
FISH technique;
chromosome
- From:Journal of Medical Research
2008;59(6):17-22
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Cystic hygromas is a common abnormal event in obstetrics ultrasound, which is induced by a chromosome disorder; it is also one of the major causes inducing fetus\u2019s congenital malformation. Objective: Determining chromosomal aberration in nuchal cystic hygromas by FISH technique and outcomes the value of factors in prognosis fetuses with cystic hygroma. Subject and methods: 53 fetuses with cystic hygroma, which are detected by ultrasound scan, are analyzed by FISH technique. Compare results of FISH, band G chromosomal analysis, ultrasonographic abnormalities, followed the fetuses. Results: Chromosomal and FISH analysis give the same detection: abnormal chromosomes: 75.46%, the highest rate is Turner syndrome: 50.94%, normal chromosome: 24.53%. Abnormal chromosomal fetuses: multi-malformation, grim prognosis. Cystic hygroma with other malformation in scan: high rate chromosomal aberrations and septated hygroma, Turner syndrome fetuses have large cystic hygroma, 4/6 fetuses with normal chromosome and without other abnormal result scan have resolutions of hygroma in the second trimester, normal birth. Conclusions: Abnormal chromosomes: 75.46%. Prognosis is grim: abnormal chromosomes, other malformations in scan, large cystic, septated hygroma. Prognosis is better: normal chromosomes, without other ultrasonographic abnormalities, small cystic, nonseptated hygroma, resolution of cystic hygroma.
