Clinics in diagnostic imaging (193). Sporadic Creutzfeldt-Jakob disease (sCJD).

Author: Jun Si Yuan LI ¹ ; Kheng Choon LIM ¹ ; Winston Eng Hoe LIM ¹ ; Robert Chun CHEN ¹
Author Information

1. Department of Diagnostic Radiology, Division of Radiological Sciences, Singapore General Hospital, Singapore.
Publication Type:Case Reports
Keywords: Creutzfeldt-Jakob disease; MR imaging; human prion disease
MeSH: Aged; Brain; pathology; Cerebral Cortex; Cerebrospinal Fluid; metabolism; Creutzfeldt-Jakob Syndrome; diagnostic imaging; Dementia; physiopathology; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; diagnostic imaging; Male; Prion Diseases; physiopathology
From:Singapore medical journal 2018;59(12):634-641
CountrySingapore
Language:English
Abstract: A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. The aetiology, clinical features, diagnostic criteria, various MR imaging patterns and radiologic differential diagnosis of sporadic Creutzfeldt-Jakob disease are discussed in this article.