Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum.
10.1016/S1875-5364(19)30005-6
- Author:
Peng-Cheng LIN
1
;
Lin-Lin JI
2
;
Xiang-Jian ZHONG
2
;
Jin-Jie LI
2
;
Xin WANG
2
;
Xiao-Ya SHANG
3
;
Sheng LIN
4
Author Information
1. College of Pharmaceutical Sciences, Qinghai University for Nationalities, Xining 810000, China.
2. Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
3. Beiijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China. Electronic address: shangxiaoya@buu.edu.cn.
4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: lsznn@imm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Cirsium setosum;
Cytotoxicity;
TNF-α secretion inhibitory activity;
Taraxastane-type triterpenoid
- MeSH:
Animals;
Cell Line, Tumor;
Cell Survival;
drug effects;
Cirsium;
chemistry;
Ether;
chemistry;
Humans;
Macrophages;
drug effects;
metabolism;
Mice;
Molecular Structure;
Plant Extracts;
chemistry;
pharmacology;
Plants, Edible;
chemistry;
Plants, Medicinal;
chemistry;
Triterpenes;
chemistry;
isolation & purification;
pharmacology;
Tumor Necrosis Factor-alpha;
metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(1):22-26
- CountryChina
- Language:English
-
Abstract:
Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC of 2.6 and 3.8 μmol·L, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
