Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.
10.1016/S1875-5364(19)30006-8
- Author:
Yu-Dan MEI
1
,
2
;
Nan ZHANG
3
;
Wei-Yang ZHANG
4
;
Jin-Shan TANG
5
;
Hua ZHOU
4
;
Yang YU
6
;
Xin-Sheng YAO
1
,
7
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
2. XiangXue Academician workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou 510663, China.
3. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
4. Faculty of Chinese Medicine, Macau University of Science and Technology and State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Macau 999078, China.
5. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.
6. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China. Electronic address: 1018yuyang@163.com.
7. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: tyaoxs@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Lonicera macranthoides;
Lonicerae Flos;
Ursane-type nortriterpenes;
iNOS
- MeSH:
Animals;
Anti-Inflammatory Agents;
chemistry;
pharmacology;
Drugs, Chinese Herbal;
chemistry;
Enzyme Inhibitors;
chemistry;
pharmacology;
Ethanol;
chemistry;
Flowers;
chemistry;
Lonicera;
chemistry;
Macrophages;
drug effects;
metabolism;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
Nitric Oxide Synthase Type II;
antagonists & inhibitors;
Plant Extracts;
chemistry;
Plants, Edible;
chemistry;
RAW 264.7 Cells;
Triterpenes;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(1):27-32
- CountryChina
- Language:English
-
Abstract:
The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L.
