Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice.
10.1016/S1875-5364(19)30007-X
- Author:
Yu WU
1
;
Wen-Jing TIAN
1
;
Shuo GAO
1
;
Zu-Jian LIAO
1
;
Guang-Hui WANG
1
;
Jir-Mehng LO
2
;
Pei-Hsin LIN
2
;
De-Quan ZENG
1
;
Da-Ren QIU
1
;
Xiang-Zhong LIU
1
;
Mi ZHOU
1
;
Ting LIN
3
;
Hai-Feng CHEN
4
Author Information
1. Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China.
2. Industrial Technology Research Institute, Taiwan 10001, China.
3. Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China. Electronic address: linting@xmu.edu.cn.
4. Fujian Provincial Key Laboratory of Innovative Drug Target, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China. Electronic address: haifeng@xmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antrodia camphorata;
Hepatoprotective;
Petri-dish
- MeSH:
Alanine Transaminase;
blood;
Aldehyde Dehydrogenase;
blood;
Animals;
Antrodia;
chemistry;
Aspartate Aminotransferases;
blood;
Biological Products;
chemistry;
pharmacology;
therapeutic use;
Chemical and Drug Induced Liver Injury;
etiology;
prevention & control;
Cholestenes;
chemistry;
pharmacology;
therapeutic use;
Cholesterol, VLDL;
blood;
Disease Models, Animal;
Ethanol;
toxicity;
Female;
Fruiting Bodies, Fungal;
chemistry;
Liver;
drug effects;
metabolism;
pathology;
Liver Diseases, Alcoholic;
prevention & control;
Male;
Malondialdehyde;
blood;
Mice;
Molecular Structure;
Triglycerides;
blood;
Triterpenes;
chemistry;
pharmacology;
therapeutic use
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(1):33-42
- CountryChina
- Language:English
-
Abstract:
Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases.
