Anti-cancer activities of S-allylmercaptocysteine from aged garlic.
10.1016/S1875-5364(19)30008-1
- Author:
Yi LV
1
;
Kwok-Fai SO
1
;
Nai-Kei WONG
2
;
Jia XIAO
3
,
4
,
5
Author Information
1. Laboratory of Neuroendocrinology, School of Biological Sciences, Fujian Normal University, Fuzhou 350117, China.
2. National Key Disciplines for Infectious Diseases, Shenzhen Third People's Hospital, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China. Electronic address: wongnksz2@163.com.
3. Laboratory of Neuroendocrinology, School of Biological Sciences, Fujian Normal University, Fuzhou 350117, China
4. National Key Disciplines for Infectious Diseases, Shenzhen Third People's Hospital, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China
5. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China. Electronic address: edwinsiu@connect.hku.hk.
- Publication Type:Journal Article
- Keywords:
Aged garlic;
Cancer;
Molecular pathway;
Reactive oxygen species;
S-allylmercaptocysteine
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
chemistry;
pharmacology;
therapeutic use;
Apoptosis;
drug effects;
Cysteine;
analogs & derivatives;
chemistry;
pharmacology;
therapeutic use;
Disease Models, Animal;
Garlic;
chemistry;
Humans;
Molecular Structure;
Neoplasms;
drug therapy;
metabolism;
Signal Transduction;
drug effects
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(1):43-49
- CountryChina
- Language:English
-
Abstract:
While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine (SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management.
