Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology.
10.1016/S1875-5364(19)30013-5
- Author:
Xiao-Rui CHENG
1
,
2
;
Chun-Hui QI
3
;
Tong-Xing WANG
1
,
2
;
Wen-Xia ZHOU
1
,
4
;
Yong-Xiang ZHANG
1
,
5
Author Information
1. Academy of Military Medical Science, Institute of Pharmacology and Toxicology, Beijing 100850, China
2. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China.
3. Academy of Military Medical Science, Institute of Pharmacology and Toxicology, Beijing 100850, China.
4. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China. Electronic address: zhouwx@bmi.ac.cn.
5. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China. Electronic address: zhangyx@bmi.ac.cn.
- Publication Type:Journal Article
- Keywords:
Liu-Wei-Di-Huang;
Pharmacokinetics;
Pharmacology;
Phytochemistry;
Toxicology;
Traditional Chinese medicine
- MeSH:
Animals;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
therapeutic use;
Humans;
Kidney;
drug effects;
Medicine, Chinese Traditional;
Neuroimmunomodulation;
drug effects;
Phytochemicals;
chemistry;
pharmacology;
therapeutic use;
Quality Control;
Yin Deficiency;
drug therapy
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(2):103-121
- CountryChina
- Language:English
-
Abstract:
Liu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
