Two symmetrical unsaturated acids isolated from Viscum album.
10.1016/S1875-5364(19)30016-0
- Author:
Duo CAO
1
,
2
;
Li-Qing WANG
3
;
Xiao-Min HAN
3
;
Hui-Rui GUAN
3
;
Meng LEI
3
;
Ya-Hui WEI
3
;
Liang CHENG
4
;
Pei-Ming YANG
5
;
Zheng-Liang SUN
6
;
Wen GAO
7
;
Jia-Kun DAI
8
Author Information
1. College of Life Science, Northwest University, Xi'an 710069, China
2. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
3. College of Life Science, Northwest University, Xi'an 710069, China.
4. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
5. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China. Electronic address: peimingy@163.com.
6. Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China. Electronic address: sunzl6@126.com.
7. Shineway Pharmaceutical Group Co., Ltd., Shijiazhuang 051430, China.
8. Bio-Agricultue Institute of Shaanxi, Shaanxi 710043, China.
- Publication Type:Journal Article
- Keywords:
Antioxidant activity;
Symmetrical unsaturated acid;
Viscum album
- MeSH:
Acetylene;
chemistry;
Antioxidants;
chemistry;
pharmacology;
Biphenyl Compounds;
chemistry;
Molecular Structure;
Picrates;
chemistry;
Plant Extracts;
chemistry;
pharmacology;
Plant Leaves;
chemistry;
Viscum album;
chemistry;
Xanthine Oxidase;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(2):145-148
- CountryChina
- Language:English
-
Abstract:
In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC of 1.22 and 1.33 μmol·L, and the SC of 4.34 and 8.22 μmol·L, respectively.
