Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.
10.1016/S1875-5364(19)30017-2
- Author:
Xiao-Wei LUO
1
,
2
;
Yun LIN
3
,
4
;
Yong-Jun LU
3
,
4
;
Xue-Feng ZHOU
1
,
5
;
Yong-Hong LIU
1
,
6
Author Information
1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2. University of Chinese Academy of Sciences, Beijing 100049, China.
3. School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China
4. Biomedical Center of Sun Yat-Sen University, Guangzhou 510275, China.
5. University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: xfzhou@scsio.ac.cn.
6. University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: yonghongliu@scsio.ac.cn.
- Publication Type:Journal Article
- Keywords:
Aspergillamides;
Aspergillus terreus;
MptpB inhibitor;
Polyketides
- MeSH:
4-Butyrolactone;
analogs & derivatives;
chemistry;
isolation & purification;
pharmacology;
Animals;
Aspergillus;
chemistry;
Chemistry Techniques, Analytical;
Dipeptides;
chemistry;
isolation & purification;
pharmacology;
Enzyme Inhibitors;
chemistry;
isolation & purification;
pharmacology;
Indoles;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Mycobacterium tuberculosis;
drug effects;
Peptides;
chemistry;
isolation & purification;
pharmacology;
Polyketides;
chemistry;
isolation & purification;
pharmacology;
Porifera;
microbiology;
Protein Tyrosine Phosphatases;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(2):149-154
- CountryChina
- Language:English
-
Abstract:
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC being 5.11 ± 0.53 μmol·L, and acted as a noncompetitive inhibitor based on kinetic analysis.
