Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach.
10.1016/S1875-5364(19)30025-1
- Author:
Lu QIU
1
;
Li HENG
1
;
Rong XU
1
;
Jun LUO
2
;
Yi LI
3
Author Information
1. Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, China.
2. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
3. Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, China. Electronic address: liyi16@163.com.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Limonoid;
Melia azedarach;
Meliaceae
- MeSH:
Animals;
Anti-Inflammatory Agents;
chemistry;
isolation & purification;
pharmacology;
Drugs, Chinese Herbal;
chemistry;
Fruit;
chemistry;
Limonins;
chemistry;
isolation & purification;
pharmacology;
Macrophages;
drug effects;
metabolism;
Melia azedarach;
chemistry;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
RAW 264.7 Cells
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(3):227-230
- CountryChina
- Language:English
-
Abstract:
Two new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC being 37.41 μmol·L.
