Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa.
10.1016/S1875-5364(19)30032-9
- Author:
Cheng-Yao MA
1
;
Jia-Hui LU
1
;
Xiang LI
2
;
Xiao LIU
3
;
Jian-Wei CHEN
4
Author Information
1. Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: lixiang_8182@163.com.
3. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing 210023, China.
4. Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: chenjw695@126.com.
- Publication Type:Journal Article
- Keywords:
Annona squamosa;
Annonaceous acetogenins;
Cytotoxicity;
Multidrug resistance
- MeSH:
Acetogenins;
chemistry;
isolation & purification;
pharmacology;
toxicity;
Annona;
chemistry;
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
toxicity;
Cell Line, Tumor;
Cell Survival;
drug effects;
Drug Resistance, Neoplasm;
drug effects;
Drug Screening Assays, Antitumor;
Humans;
Molecular Structure;
Plant Extracts;
chemistry;
pharmacology;
toxicity;
Seeds;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(4):291-297
- CountryChina
- Language:English
-
Abstract:
Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.
