Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica.
10.1016/S1875-5364(19)30033-0
- Author:
Lin CHEN
1
;
Jia-Luo HUANG
1
;
Lei ZHANG
1
;
Hai-Yan TIAN
2
;
Sheng YIN
3
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
3. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: yinsh2@mail.sysu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory activity;
Diterpenoids;
Euphorbiaceae;
Jatropha podagrica
- MeSH:
Animals;
Anti-Inflammatory Agents;
chemistry;
pharmacology;
Carbon;
analysis;
Diterpenes;
chemistry;
pharmacology;
Inhibitory Concentration 50;
Jatropha;
chemistry;
Lipopolysaccharides;
toxicity;
Macrophages;
drug effects;
metabolism;
Mice;
Molecular Structure;
Nitric Oxide;
metabolism;
Plant Extracts;
chemistry;
pharmacology;
Plant Stems;
chemistry;
RAW 264.7 Cells
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(4):298-302
- CountryChina
- Language:English
-
Abstract:
Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC of 13.44 ± 0.28 μmol·L, being comparable to the positive control, quercetin (IC 17.00 ± 2.10 μmol·L).
