New octadecanoid derivatives from the seeds of Ipomoea nil.
10.1016/S1875-5364(19)30034-2
- Author:
Xiu-Qing SONG
1
,
2
;
Jun-Sheng ZHANG
3
;
Shu-Juan YU
1
,
2
;
Jin-Hai YU
3
;
Hua ZHANG
4
Author Information
1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
3. School of Biological Science and Technology, University of Jinan, Jinan 250022, China.
4. School of Biological Science and Technology, University of Jinan, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
- Publication Type:Journal Article
- Keywords:
Fatty acid;
Ipomoea nil;
Natural enantiomer;
Octadecanoid;
α-Glucosidase inhibition
- MeSH:
Fatty Acids;
chemistry;
isolation & purification;
metabolism;
Glycoside Hydrolase Inhibitors;
chemistry;
isolation & purification;
metabolism;
Inhibitory Concentration 50;
Ipomoea nil;
chemistry;
Molecular Structure;
Plant Extracts;
chemistry;
metabolism;
Seeds;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(4):303-307
- CountryChina
- Language:English
-
Abstract:
Four new octadecanoid derivatives (1-4) including a pair of enantiomers (1/2), along with 12 known analogues (5-16), were isolatedfrom the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better α-glucosidase inhibitory activity than the positive control acarbose (IC 167.7 ± 1.55 μmol·L), with IC of 92.73 ± 3.12 and 11.39 ± 2.18μmol·L, respectively.
