Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation.
10.1016/S1875-5364(19)30052-4
- Author:
Da LI
1
;
Jian-Qi XIAO
1
;
Wen-Yuan LIU
2
;
Chao-Feng ZHANG
2
;
Toshihiro AKIHISA
3
;
Masahiko ABE
3
;
Eliot-T MASTERS
4
;
Wei-Wei ZHAI
1
;
Feng FENG
5
,
6
,
7
;
Jie ZHANG
8
,
9
Author Information
1. Jiangsu Food and Pharmaceutical Science College, Huai'an 223003, China.
2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
3. Research Institute for Science and Technology, Tokyo University of Science, Chiba 278-8510, Japan.
4. World Agroforestry Centre (ICRAF), Nelson Marlbolough Institute of Technology (NMIT), Nelson 7010, New Zealand.
5. Jiangsu Food and Pharmaceutical Science College, Huai'an 223003, China
6. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
7. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China. Electronic address: fengfeng@cpu.edu.cn.
8. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
9. Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China. Electronic address: cpunmc_zj@163.com.
- Publication Type:Journal Article
- Keywords:
Antioxidant activity;
HPLC fingerprints;
Molecular docking;
Vitellaria paradoxa;
α-Glucosidase inhibitory activity
- MeSH:
Africa South of the Sahara;
Chromatography, High Pressure Liquid;
Diabetes Mellitus;
drug therapy;
enzymology;
Glycoside Hydrolase Inhibitors;
chemistry;
pharmacology;
Humans;
Hypoglycemic Agents;
chemistry;
pharmacology;
Molecular Docking Simulation;
Plant Extracts;
chemistry;
pharmacology;
Plants, Medicinal;
chemistry;
Sapotaceae;
chemistry;
alpha-Glucosidases;
metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(6):446-460
- CountryChina
- Language:English
-
Abstract:
The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. Twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin, (2R, 3R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. The study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes.
