Withaminimas A-F, six withanolides with potential anti-inflammatory activity from Physalis minima.
10.1016/S1875-5364(19)30054-8
- Author:
Shan-Shan WEI
1
;
Cai-Yun GAO
1
;
Rui-Jun LI
1
;
Ling-Yi KONG
2
;
Jun LUO
3
Author Information
1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: cpu_lykong@126.com.
3. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojun@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Physalis minima;
Withaphysalin-type withanolides
- MeSH:
Animals;
Anti-Inflammatory Agents;
chemistry;
pharmacology;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Lipopolysaccharides;
pharmacology;
Macrophages;
drug effects;
immunology;
Mice;
Molecular Structure;
Physalis;
chemistry;
RAW 264.7 Cells;
Structure-Activity Relationship;
Withanolides;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(6):469-474
- CountryChina
- Language:English
-
Abstract:
Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC values among 3.91-18.46 μmol·L.
