Bioactive phenazines from an earwig-associated Streptomyces sp.
10.1016/S1875-5364(19)30055-X
- Author:
Hao HAN
1
;
Zhi-Kai GUO
2
;
Bo ZHANG
1
;
Mei ZHANG
1
;
Jing SHI
1
;
Wei LI
1
;
Rui-Hua JIAO
1
;
Ren-Xiang TAN
3
,
4
;
Hui-Ming GE
5
Author Information
1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
2. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
3. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China
4. State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
5. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address: hmge@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acetylcholinesterase inhibitory activity;
Antimicrobial activity;
Biosynthetic pathway;
Earwig-associated actinomycete;
Phenazine
- MeSH:
Animals;
Anti-Bacterial Agents;
chemistry;
metabolism;
pharmacology;
Bacterial Proteins;
genetics;
metabolism;
Crystallography, X-Ray;
Insecta;
microbiology;
Magnetic Resonance Spectroscopy;
Microbial Sensitivity Tests;
Micrococcus luteus;
drug effects;
Molecular Structure;
Multigene Family;
Phenazines;
chemistry;
metabolism;
pharmacology;
Streptomyces;
chemistry;
genetics;
metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(6):475-480
- CountryChina
- Language:English
-
Abstract:
Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a biosynthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.
