Therapeutic effects of garlic in cardiovascular atherosclerotic disease.
10.1016/S1875-5364(19)30088-3
- Author:
Igor A SOBENIN
1
,
2
,
3
;
Veronika A MYASOEDOVA
4
;
Maria I ILTCHUK
4
;
Dong-Wei ZHANG
5
;
Alexander N OREKHOV
6
,
7
Author Information
1. National Medical Research Center of Cardiology, 121552 Moscow, Russian Federation
2. Institute of General Pathology and Pathophysiology, 125315 Moscow, Russian Federation
3. Research Institute of Threpsology and Healthy Longevity, Plekhanov Russian University of Economics, 117997 Moscow, Russian Federation.
4. Institute of General Pathology and Pathophysiology, 125315 Moscow, Russian Federation.
5. Diabetes Research Center, Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
6. Institute of General Pathology and Pathophysiology, 125315 Moscow, Russian Federation
7. Institute of Human Morphology, 117418 Moscow, Russian Federation. Electronic address: a.h.opexob@gmail.com.
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Cardiovascular disease;
Dyslipidemia;
Garlic;
Natural medicines
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(10):721-728
- CountryChina
- Language:English
-
Abstract:
Garlic (Allium sativum) is a widely known medicinal plant, potential of which remains to be fully evaluated. Its wide-range beneficial effects appear to be relevant for treatment and prevention of atherosclerosis and related diseases. It is generally believed that garlic-based preparations are able to improve lipid profile in humans, inhibit cholesterol biosynthesis, suppress low density lipoprotein oxidation, modulate blood pressure, suppress platelet aggregation, lower plasma fibrinogen level and increase fibrinolytic activity, thus providing clinically relevant cardioprotective and anti-atherosclerotic effects. It is important to assess the level of evidence available for different protective effects of garlic and to understand the underlying mechanisms. This information will allow adequate integration of garlic-based preparations to clinical practice. In this review, we discuss the mechanisms of anti-atherosclerotic effects of garlic preparations, focusing on antihyperlipidemic, hypotensive, anti-platelet and direct anti-atherosclerotic activities of the medicinal plant. We also provide an overview of available meta-analyses and a number of clinical trials that assess the beneficial effects of garlic.
