The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer.
10.1016/S1875-5364(19)30089-5
- Author:
Liang-Qin WAN
1
;
Yan TAN
1
;
Miao JIANG
2
;
Qian HUA
3
Author Information
1. School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China.
2. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: doctorjiang@139.com.
3. School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: hqianz@aliyun.com.
- Publication Type:Journal Article
- Keywords:
Immunotherapy;
Lung cancer;
Traditional Chinese medicine (TCM) monomer;
Tumor microenvironment;
Tumor-associated macrophages
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(10):729-737
- CountryChina
- Language:English
-
Abstract:
Non-small cell lung cancer (NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages (TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1 (tumor-inhibitory) phenotype or M2 (tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine (TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.
