Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica.
10.1016/S1875-5364(19)30095-0
- Author:
Abilova ZHAMILYA
1
,
2
;
Jie YUAN
1
,
2
;
Jenis JANAR
3
,
4
;
Chun-Ping TANG
5
;
Yang YE
3
,
6
Author Information
1. University of Chinese Academy of Sciences, Beijing 100049, China
2. State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
3. State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
4. Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi ave. 71, 050040 Almaty, Republic of Kazakhstan.
5. State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
6. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: yye@shcnc.ac.cn.
- Publication Type:Journal Article
- Keywords:
Ajaniaolide B;
Anti-inflammation;
Artemdubolide I;
Artemisia heptapotamica;
Artemisiane E;
Sesquiterpene lactone
- From:
Chinese Journal of Natural Medicines (English Ed.)
2019;17(10):785-791
- CountryChina
- Language:English
-
Abstract:
One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC values ranging from 2 to 25 μmol·L.
