A case with a novel weak D type.
10.3760/cma.j.issn.1003-9406.2019.07.019
- Author:
Yunlei HE
1
;
Lu YU
;
Deyi XU
;
Wenyu GUO
;
Gang DENG
Author Information
1. Ningbo Central Blood Station, Zhejiang 315000, China. 80625346@qq.com.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
China;
Exons;
Genotype;
Humans;
Introns;
Rh-Hr Blood-Group System;
genetics
- From:
Chinese Journal of Medical Genetics
2019;36(7):731-733
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To report on a novel weak D type identified in a Chinese individual.
METHODS:Peripheral blood sample was collected for a voluntary blood donor with weakened expression of D antigen. Routine serological testing was carried out to determine the D, C, c, E and e antigens of the Rh blood group. A D-screening kit was used to analyze the RhD epitopes. The 10 exons and flanking intronic regions of the RHD gene were sequenced. The zygosity of RHD was determined with a sequence-specific primer PCR method.
RESULTS:A novel RHD allele, RHD (1022T>A), was found in the subject with a weak D phenotype. Serological testing of the RhD epitopes has coined with the weak D phenotype.
CONCLUSION:A novel weak D allele has been identified in Chinese population.
