Progress of research on Maple syrup disease.

VernacularTitle:枫糖尿病的研究进展
Author: Caifei YANG ¹ ; Tao CHEN ; Xiaoguang LEI ; Yuexian LIU ; Mengyuan XU ; Dan YANG
Author Information

1. Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunan 650032, China. ydanabc@126.com.
Publication Type:Journal Article
MeSH: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); genetics; Humans; Maple Syrup Urine Disease; diagnosis; genetics; therapy; Mutation
From: Chinese Journal of Medical Genetics 2019;36(7):737-741
CountryChina
Language:Chinese
Abstract: Maple syrup disease (MSUD) is a rare autosomal recessive disorder caused primarily by mutations of branched-chain keto acid dehydrogenase complex (BCKDC). BCKDC includes at least four pathogenic genes of BCKDHA, BCKDHB, DLD and DBT. The clinical manifestations of MSUD are complex, and the main symptoms at the early stage include difficulty in feeding, drowsiness, change in muscle tone and special urine flavor of maple syrup. As the disease progresses, convulsion, hypoglycemia, coma and systemic failure may occur. MSUD is easily missed or misdiagnosed during the neonatal period. This paper provides a review for recent progress made in research on MSUD including etiology, physiopathology, clinical manifestation, auxiliary examination and treatment, with a particular emphasis on genetic testing and treatment.