Analysis of hematological phenotype and genotype of Hb Q-Thailand in Fujian area.
10.3760/cma.j.issn.1003-9406.2019.08.002
- Author:
Lingji CHEN
1
;
Meihuan CHEN
;
Min ZHANG
;
Yan WANG
;
Hailong HUANG
;
Ying LI
;
Liangpu XU
Author Information
1. Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Provincial Maternity and Children' s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China. ipxiu304@126.com.
- Publication Type:Journal Article
- MeSH:
China;
Genotype;
Hemoglobins, Abnormal;
genetics;
Heterozygote;
Humans;
Mutation;
Phenotype
- From:
Chinese Journal of Medical Genetics
2019;36(8):761-764
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the hematological phenotype and genotype of hemoglobin Q-Thailand in Fujian area.
METHODS:Genomic DNA was extracted from peripheral venous blood samples of patients. Suspected samples were screened by hematological parameters analysis and verified with DNA sequencing.
RESULTS:In 35 patients suspected with Hb Q-Thailand, 20 were confirmed, which included one case compounded with heterozygous β mutation and one compounded with Hb New York.
CONCLUSION:Analysis of hematological phenotype and genotype of Hb Q-Thailand can faciliate genetic counseling for patients from Fujian area.
