A protective effect conferred by KIR3DL1 and its cognate ligand against cervical cancer among ethnic Han Chinese population and its potential mechanism.
10.3760/cma.j.issn.1003-9406.2019.10.022
- VernacularTitle:中国汉族人群中KIR3DL1及其配体对宫颈癌的保护性作用及机制探讨
- Author:
Jianxin ZHEN
1
;
Leilei ZHU
;
Weihong LI
;
Haiyan HU
;
Zhihui DENG
;
Likuan XIONG
Author Information
1. Central Laboratory, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong 518133, China. xionglk@sina.cn.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
China;
Ethnic Groups;
Female;
HLA-B Antigens;
genetics;
Humans;
Protective Factors;
Receptors, KIR;
Receptors, KIR3DL1;
genetics;
Uterine Cervical Neoplasms;
genetics
- From:
Chinese Journal of Medical Genetics
2019;36(10):1035-1038
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of inhibitory KIR (iKIR) and its cognate HLA ligand in the occurrence and development of cervical cancer among ethnic Han Chinese and its potential mechanism.
METHODS:Peripheral blood samples from 265 Han Chinese patients with cervical intraepithelial neoplasia (CIN)/cervical cancer and 200 ethnically matched healthy controls were collected. The results of KIR PCR-SSP, HLA PCR-rSSO and KIR3DL1 PCR-SBT, together with cervical cancer data from the TCGA database, were used to assess the association of iKIR genes, receptor-ligand gene combinations, iKIR transcription level in the tumor tissue and the KIR3DL1 alleles with the occurrence and development of cervical cancer.
RESULTS:Among the four iKIR genes (KIR2DL1, 2DL2/3, 3DL1 and 3DL2), the frequencies of KIR3DL1 and KIR3DL1-HLA-Bw4 genes among controls were significantly higher than those of the cervical cancer group (96.5% vs. 87.0%, P = 0.018; 81.5% vs. 64.8%, P=0.009). The survival rate of cervical cancer patients with a high transcription level of KIR3DL1 in tumor tissues was significantly higher than those with a low/medium transcription level (P=0.028). The frequency of strong-inhibitory and high-expression KIR3DL1*01502 allele among the healthy population was significantly higher than that of the cervical cancer group (76.0% vs. 59.3%, P =0.015).
CONCLUSION:Combined KIR3DL1 and KIR3DL1-HLA-Bw4 can confer a protective effect against the development of cervical cancer, which may be attributed to the strong-inhibitory and high-expression allele of KIR3DL1*01502.
