Roles of hyaluronan in cardiovascular and nervous system disorders.

Author: Hong-Yan DING ¹ ; Ya-Nan XIE ¹ ; Qiang DONG ¹ ; Koji KIMATA ² ; Yoshihiro NISHIDA ³ ; Naoki ISHIGURO ³ ; Li-Sheng ZHUO ³
Author Information

1. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
2. Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
3. Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Publication Type:Journal Article
Keywords: Hyaluronic acid; Extracellular matrix; Cardiovascular vessel; Heart; Brain
From: Journal of Zhejiang University. Science. B 2019;20(5):428-436
CountryChina
Language:English
Abstract: Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.