Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment.

Jie Luo; Yan Xiong; Pei-fen FU; En-chun LI; Lei QU; Xiao Fan; Zhi-jian Cai; Ai-fu Lin

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Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment.

Author: Jie LUO ¹ ; Yan XIONG ² ; Pei-Fen FU ³ ; En-Chun LI ¹ ; Lei QU ⁴ ; Xiao FAN ⁴ ; Zhi-Jian CAI ⁵ ; Ai-Fu LIN ³
Author Information

1. Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
2. Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
3. The Breast Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
4. MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.
5. Institute of Immunology, and Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Publication Type:Journal Article
Keywords: Exosome; Long non-coding RNA (lncRNA); Biosynthesis; Biomarker; Drug resistance
MeSH: Exosomes; physiology; Humans; Neoplasms; diagnosis; genetics; therapy; RNA, Long Noncoding; physiology
From: Journal of Zhejiang University. Science. B 2019;20(6):488-495
CountryChina
Language:English
Abstract: Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.