A visualization analysis of current research on stem cell transplantation in the treatment of neonatal hypoxic-ischemic encephalopathy.
- Author:
Wen-Xing LI
1
;
Jun TANG
;
Rong ZOU
;
Yan ZENG
;
Yan YUE
;
Xia QIU
;
Yi QU
;
De-Zhi MU
Author Information
1. Department of Pediatrics, West China Second University Hospital/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China. tj1234753@sina.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Hypoxia-Ischemia, Brain;
Infant, Newborn;
Mesenchymal Stem Cells;
Neural Stem Cells;
Stem Cell Transplantation
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(12):1002-1007
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To reveal the current research status on stem cell transplantation in the treatment of neonates with hypoxic-ischemic encephalopathy (HIE), and to summarize the recent hotspots of the research in this field.
METHODS:Using the key words of "stem cells" and "HIE", a computerized search was performed for the articles in English published before June 1, 2018 in PubMed, EMBASE, and Web of Science. Microsoft Office Excel 2013 was used for the statistical analysis of key words. Bicomb 2.0 and VOSviewer 1.6.6 were used for the cluster analysis of hot words and plotting of knowledge maps, respectively.
RESULTS:A total of 106 articles were included and 43 high-frequency key words were extracted. The words of "cell transplantation" and "hypoxia-ischemia" were in the core position of the co-word map. The cluster analysis showed that the studies of stem cell transplantation in the treatment of neonatal HIE mainly focused on umbilical cord blood cell transplantation (32.6%), mesenchymal stem cells and neural stem cells (29.5%), perinatal brain injury (28.1%), and other topics (9.8%).
CONCLUSIONS:In the current studies of stem cell transplantation in the treatment of neonatal HIE, umbilical cord blood cell transplantation, mesenchymal stem cells, neural stem cells, and perinatal brain injury are popular research topics at different levels.
