Protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus.
- Author:
Yong-Xing CHEN
1
;
Qiong CHEN
;
Ying-Xian ZHANG
;
Fang LIU
;
Hai-Hua YANG
;
Sheng-Nan WU
;
Hai-Yan WEI
Author Information
1. Department of Endocrinology and Inherited Metabolism, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China. haiyanwei2009@163.com.
- Publication Type:Journal Article
- MeSH:
Blood Glucose;
C-Peptide;
Diabetes Mellitus, Type 1;
Glycated Hemoglobin A;
Humans;
Infant;
Insulin;
Insulin-Secreting Cells;
Vitamin A
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(12):1020-1023
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus (T1DM) and its mechanism.
METHODS:A total of 46 children with T1DM (with a course of disease of 0.5-1 year) were randomly divided into an intervention group and a non-intervention group (n=23 each). The children in both groups were given insulin treatment, and those in the intervention group were also given vitamin A at a daily dose of 1 500-2 000 IU. A total of 25 healthy children were enrolled as the control group. The daily dose of insulin was calculated for the children with T1DM, and the serum levels of glycosylated hemoglobin (HbA1C), stimulated C-peptide, vitamin A, and interleukin-17 (IL-17) were measured before intervention and 3 months after intervention.
RESULTS:Before vitamin A intervention, the intervention group and the non-intervention group had a significantly lower serum level of vitamin A and a significantly higher level of IL-17 than the control group (P<0.01). After 3 months of intervention, the intervention group had significantly lower serum IL-17 level and insulin dose and a significantly higher level of stimulated C-peptide than the non-intervention group (P<0.05).
CONCLUSIONS:Vitamin A may protect residual pancreatic β cell function, possibly by improving the abnormal secretion of IL-17 in children with T1DM.
