Prevalence of Bordetella pertussis infection in children with chronic cough and its clinical features.
- Author:
Dan-Xia WU
1
;
Qiang CHEN
;
Lan LI
;
Kun-Ling SHEN
;
Kai-Hu YAO
Author Information
1. Department of Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang 330006, China. jx-cq@163.com.
- Publication Type:Journal Article
- MeSH:
Azithromycin;
Bordetella pertussis;
Child;
Humans;
Prevalence;
Whooping Cough;
epidemiology
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(1):18-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the prevalence of Bordetella pertussis infection in children with chronic cough and its clinical features.
METHODS:A total of 106 children who were treated at the outpatient service or hospitalized from January 1, 2016 to May 31, 2017 were enrolled. Their nasopharyngeal swabs and venous blood samples were collected for Bordetella pertussis culture, multiple PCR and serum anti-pertussis toxin antibody detection. According to these results, the children were divided into pertussis group with 26 children and control group with 80 children, and clinical features were analyzed for both groups. E-test stripes were used to determine the sensitivity of Bordetella pertussis strains to erythromycin, azithromycin, doxycycline, levofloxacin, sulfamethoxazole/trimethoprim and amoxicillin.
RESULTS:Of the 106 children with chronic cough, 26 (24.5%) were found to have Bordetella pertussis infection. There were no significant differences in the incidence rates of typical symptoms of pertussis between the pertussis and control groups (P>0.05). E-test showed that erythromycin and azithromycin had a minimal inhibitory concentration (MIC) of >256 mg/L against five Bordetella pertussis strains, while amoxicillin had an MIC of 0.5-1 mg/L.
CONCLUSIONS:The presence of Bordetella pertussis infection in children with chronic cough should be taken seriously by clinicians, and children with chronic cough and Bordetella pertussis infection may not have the typical symptoms of pertussis and are mainly manifested as chronic cough. Amoxicillin may be an alternative drug for macrolide-resistant Bordetella pertussis infection.
