Effects of Mitochondrial Dysfunction via AMPK/PGC-1 α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine.
10.1007/s11655-018-2579-0
- Author:
Qian ZHANG
1
;
Xiao-Chun LIANG
2
Author Information
1. Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
2. Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. xcliang@vip.sina.com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
diabetic peripheral neuropathy;
monophosphate-activated protein kinase;
peroxisome proliferator-activated receptor- γ coactivator 1 α;
sirtuins
- MeSH:
AMP-Activated Protein Kinases;
metabolism;
Diabetic Neuropathies;
drug therapy;
pathology;
Humans;
Medicine, Chinese Traditional;
Mitochondria;
metabolism;
pathology;
Neuroprotective Agents;
therapeutic use;
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha;
metabolism;
Signal Transduction
- From:
Chinese journal of integrative medicine
2019;25(5):386-394
- CountryChina
- Language:English
-
Abstract:
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1 α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1 α pathway and improving mitochondrial function.
