Effects of aerobic exercise and glutamine on oxidative stress and expression of related factors in type 2 diabetic rats.
10.12047/j.cjap.5777.2019.033
- Author:
Xiao Mei WANG
1
;
Hui Feng JING
1
Author Information
1. Institute of Physical Education,Yanan University, Yanan 716000, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Glucose;
analysis;
Diabetes Mellitus, Experimental;
Diabetes Mellitus, Type 2;
therapy;
Glutamine;
pharmacology;
Leptin;
blood;
Lipid Metabolism;
Lipids;
blood;
Male;
Malondialdehyde;
blood;
Oxidative Stress;
Physical Conditioning, Animal;
Random Allocation;
Rats;
Rats, Sprague-Dawley
- From:
Chinese Journal of Applied Physiology
2019;35(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of aerobic exercise and glutamine (Gln) on anti-oxidative stress and inflammatory factors in type 2 diabetes mellitus (T2MD) rats.
METHODS:Diabetic rat model was induced by streptozotocin (STZ). Fifty 6-week old male SD rats were randomly divided into 5 groups (n=10), including quiet control group (N), diabetes control group (D), diabetic aerobic exercise group (DE), diabetic glutamine group (DG) and diabetic aerobic exercise glutamine group (DEG). After 6 weeks, the related indicators of glucose and lipid metabolism, anti-oxidative stress and inflammatory factors in diabetic rats were detected, and the possible mechanism affecting inflammatory response were explored.
RESULTS:Compared with group N, the levels of serum malondialdehyde(MDA), blood glucose, total cholesterol(TC), triglyceride(TG), insulin, leptin and tumor necrosis factor-α(TNF-α) in group D were increased significantly (P＜0.01). Compared with group D, serum levels of MDA, blood glucose, TC, TG, insulin, leptin and TNF-α in three intervention groups were decreased significantly, while the levels of SOD, GSH-Px and adiponectin were increased, and the combined effect was more obvious (P＜0.01).
CONCLUSION:Both aerobic exercise and Gln can relieve the glucose and lipid metabolism and disturbance, oxidative stress injury and inflammation in diabetic rats.
