Effects of ginsenoside-Rg on mechanical allodynia, heat hyperalgeia, depressive state of rats with chronic sciatic nerve constriction injury.
10.12047/j.cjap.5763.2019.049
- Author:
Qiao-Lian ZHANG
1
;
Shuang-Ying LI
1
;
Ping LI
1
Author Information
1. Department of Neurology, Characteristic Medical Center of the Chinese People's Armed Police Forces, Tianjin 300162, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Constriction;
Ginsenosides;
pharmacology;
Hot Temperature;
adverse effects;
Hyperalgesia;
drug therapy;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Sciatic Nerve;
injuries
- From:
Chinese Journal of Applied Physiology
2019;35(3):228-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of ginsenoside-Rg on mechanical allodynia, heat hyperalgeia, depressive state of rats with chronic sciatic nerve constriction injury.
METHODS:Fifty SD rats were randomly divided into 5 groups: blank control group (Normal, normal + saline),sham operation group (Sham, sham operation + saline),chronic constriction injury of the sciatic nerve group (CCI, CCI + saline),ginsenoside-Rg low dose group (CCI + Rg 5 mg/kg), and ginsenoside-Rg high dose group (CCI + Rg 10 mg/kg).After the CCI model was established,drug were injected into the abdominal cavity through the syringe once a day,for 14 consecutive days.The mechanical shrinkage foot reflex threshold (MWT) and thermal withdrawal latency(TWL) were determined at 1 d before the operation and at 1,3,5,7,10 and 14 d after the operation.Light-dark transition test, forced swimming test were determined at 1 d before the operation and at 14 d after the operation.
RESULTS:Compared with the sham group, the MWL and TWL of the CCI rats were decreased significantly (P＜0.01), time in the light compartment and number of transition were decreased (P＜0.01), the immobility time in FST was also prolonged significantly (P＜0.01). At 14 days after CCI operation, the MWL and TWL of the ginsenoside-Rg groups were increased significantly (P＜0.01), time in the light compartment and number of transition were also shortened significantly (P＜0.01), the immobility time in FST was also shortened significantly (P＜0.01).
CONCLUSION:Intraperitoneal injection of ginsenoside-Rg can inhibit the mechanical and thermal pain sensitivity of CCI rats,and can relieve depressive state.
