Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms.
10.1007/s12264-019-00357-w
- Author:
Lingling CUI
1
;
Fei WANG
1
;
Miao CHANG
1
;
Zhiyang YIN
2
;
Guoguang FAN
1
;
Yanzhuo SONG
2
;
Yange WEI
2
;
Yixiao XU
2
;
Yifan ZHANG
2
;
Yanqing TANG
3
;
Xiaohong GONG
4
;
Ke XU
5
Author Information
1. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
2. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
3. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. yanqingtang@163.com.
4. State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China. gongxh@fudan.edu.cn.
5. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. kxu@cmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Amplitudes of low-frequency fluctuations;
Catechol-O-methyltransferase;
Zinc finger protein 804A;
fMRI
- From:
Neuroscience Bulletin
2019;35(4):735-742
- CountryChina
- Language:English
-
Abstract:
ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Here, we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants. Amplitudes of low-frequency fluctuations (ALFFs) were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680. The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 × COMT rs4680 interaction, manifesting as a U-shaped modulation, presumably by dopamine signaling. Significant main effects were also found. These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT, and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.
