Research on network pharmacology of alkaloids in Sophora alopecuroides.
10.19540/j.cnki.cjcmm.20171027.017
- Author:
Bo-Yang SHANG
1
;
Ping YANG
2
;
Li CHEN
1
;
Xiao-Juan GAO
1
;
Jing-Jiao YONG
1
;
Xia ZHANG
1
;
Jian-Jun ZHAO
1
;
Han-Qing WANG
1
Author Information
1. College of Pharmacy， Ningxia Medical University， Yinchuan 750004， China.
2. Division of Neonatology, General Hospital of Ningxia Medical University， Yinchuan 750004， China.
- Publication Type:Journal Article
- Keywords:
Sophora alopecuroides;
alkaloid;
network pharmacology;
signaling pathway;
target
- MeSH:
Alkaloids;
pharmacology;
Phytochemicals;
pharmacology;
Signal Transduction;
drug effects;
Sophora;
chemistry
- From:
China Journal of Chinese Materia Medica
2018;43(1):160-167
- CountryChina
- Language:Chinese
-
Abstract:
It was aimed at exploring the potential pharmacological effects of alkaloids in Sophora alopecuroides by means of network pharmacology in this study. The main alkaloids in S. alopecuroides were collected for analysis of drug properties, prediction of potential targets and screening of signaling pathways. DAVID analysis tool combined with KEGG database was used to annotate and analyze the signaling pathway. The alkaloids-targets-signaling pathways network was built through Cytoscape software. Results showed that 17 alkaloids in S. alopecuroides involved 49 targets (170 times in all) and 22 important signaling pathways. Three nodes in model of network pharmacology were cross-linked, and the metabolic pathways were coordinated and regulated by each other. It indicated that alkaloids in S. alopecuroides may have therapeutic effect on diseases of cancer, metabolic disorder, endocrine system, digestive system, nervous system and so on.
