Application of network biology on study of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20171027.018
- Author:
Sai-Sai TIAN
1
;
Jian YANG
1
;
Jing ZHAO
2
;
Wei-Dong ZHANG
1
Author Information
1. College of Pharmacy, the Second Military Medical University, Shanghai 200433， China.
2. Institute of Interdisciplinary Complex Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203， China.
- Publication Type:Journal Article
- Keywords:
complex diseases;
holism;
multi-target drug;
network biology;
syndrome differentiation and treatment;
traditional Chinese medicine
- MeSH:
Drug Discovery;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Systems Biology
- From:
China Journal of Chinese Materia Medica
2018;43(2):274-280
- CountryChina
- Language:Chinese
-
Abstract:
With the completion of the human genome project, people have gradually recognized that the functions of the biological system are fulfilled through network-type interaction between genes, proteins and small molecules, while complex diseases are caused by the imbalance of biological processes due to a number of gene expression disorders. These have contributed to the rise of the concept of the "multi-target" drug discovery. Treatment and diagnosis of traditional Chinese medicine are based on holism and syndrome differentiation. At the molecular level, traditional Chinese medicine is characterized by multi-component and multi-target prescriptions, which is expected to provide a reference for the development of multi-target drugs. This paper reviews the application of network biology in traditional Chinese medicine in six aspects, in expectation to provide a reference to the modernized study of traditional Chinese medicine.
