Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis.
10.3779/j.issn.1009-3419.2018.01.01
- Author:
Dongfeng YUAN
1
;
Zhitao GU
2
;
Guanghui LIANG
1
;
Wentao FANG
2
;
Yin LI
1
;
Chinese Alliance for Research of Thymoma Database
Author Information
1. Department of Thoracic Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.
2. Shanghai Chest Hospital, Affiliated to Shanghai Jiaotong University, Shanghai 200030, China.
- Collective Name:Chinese Alliance for Research of Thymoma Database
- Publication Type:Journal Article
- Keywords:
Extended thymectomy;
Myasthenia gravis;
Prognosis;
Thymoma
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Female;
Humans;
Male;
Middle Aged;
Myasthenia Gravis;
complications;
diagnosis;
surgery;
Prognosis;
Retrospective Studies;
Survival Analysis;
Thymoma;
complications;
Young Adult
- From:
Chinese Journal of Lung Cancer
2018;21(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors.
METHODS:A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way.
RESULTS:Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ²=24.908, P<0.001). MG: incidence of B2 type (58/178, 32.58%) > B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ²=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P<0.05), and whether the merger MG (χ²=0.113, P=0.736), postoperative adjuvant radiotherapy (χ²=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ²=14.417, P<0.001). Whether has nothing to do with the prognosis of the thymus resection (χ²=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ²=24.695, P<0.001).
CONCLUSIONS:Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.
