Progress of Long Non-coding RNA in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2018.01.06
- Author:
Yachen ZHANG
1
;
Di LIANG
1
;
Jing JIN
1
;
Congmin LIU
1
;
Yutong HE
1
Author Information
1. The Fourth Hospital of Heibei Medical University, Cancer Institute, Shijiazhuang 050011, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
LncRNA;
Lung neoplasms;
Prognosis;
Treatment
- MeSH:
Carcinogenesis;
genetics;
Carcinoma, Non-Small-Cell Lung;
diagnosis;
drug therapy;
genetics;
pathology;
Humans;
Molecular Targeted Therapy;
RNA, Long Noncoding;
genetics
- From:
Chinese Journal of Lung Cancer
2018;21(1):43-49
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation, differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therpy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurence, diagnosis, therpy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.
